Soon he appeared in numerous commercials for brands like Abercrombie and Fitch, Mountain Dew and Starburst.
In the year 2004, he appeared in the films Spellbound and Little Black Book.
Annable learned acting at the Neighborhood Playhouse in New York.
Before leaving State University of New York, he had made his acting debut by appearing in an occurrence of the NBC crime drama Third Watch in 2002.
While attending the college, he was involved with the student-run TV station, Plattsburgh State Television where he worked on both productions on the air and behind the scenes as well.